2024
Evaluation of all-cause mortality and cardiovascular safety in patients receiving chimeric antigen receptor T cell therapy: a prospective cohort study. F Korell, L Entenmann, S Romann, E Giannitsis, A Schmitt, C Müller-Tidow, N Frey, P Dreger, M Schmitt, LH Lehmann. https://doi.org/10.1016/j.eclinm.2024.102504 Lancet eClinicalMedicine volume 69
2023
Advancing the care of individuals with cancer through innovation & technology: Proceedings from the cardiology oncology innovation summit 2020 and 2021. Brown SA, Beavers C, Bauer B, Cheng RK, Berman G, Marshall CH, Guha A, Jain P, Steward A, DeCara JM, Olaye IM, Hansen K, Logan J, Bergom C, Glide-Hurst C, Loh I, Gambril JA, MacLeod J, Maddula R, McGranaghan PJ, Batra A, Campbell C, Hamid A, Gunturkun F, Davis R, Jefferies J, Fradley M, Albert K, Blaes A, Choudhuri I, Ghosh AK, Ryan TD, Ezeoke O, Leedy DJ, Williams W, Roman S, Lehmann L, Sarkar A, Sadler D, Polter E, Ruddy KJ, Bansal N, Yang E, Patel B, Cho D, Bailey A, Addison D, Rao V, Levenson JE, Itchhaporia D, Watson K, Gulati M, Williams K, Lloyd-Jones D, Michos E, Gralow J, Martinez H.Am Heart J Plus. 2023 Dec 25;38:100354. doi: 10.1016/j.ahjo.2023.100354. eCollection 2024 Feb.
Cardiological parameters predict mortality and cardiotoxicity in oncological patients. Romann SW, Finke D, Heckmann MB, Hund H, Giannitsis E, Katus HA, Frey N, Lehmann LH.ESC Heart Fail. 2024 Feb;11(1):366-377. doi: 10.1002/ehf2.14587. Epub 2023 Nov 27.PMID: 38012070
Thymus alterations and susceptibility to immune checkpoint inhibitor myocarditis. Fenioux C, Abbar B, Boussouar S, Bretagne M, Power JR, Moslehi JJ, Gougis P, Amelin D, Dechartres A, Lehmann LH, Courand PY, Cautela J, Alexandre J, Procureur A, Rozes A, Leonard-Louis S, Qin J; International ICI-Myocarditis Registry; Cheynier R, Charmeteau-De Muylder B, Redheuil A, Tubach F, Cadranel J, Milon A, Ederhy S, Similoswki T, Johnson DB, Pizzo I, Catalan T, Benveniste O, Hayek SS, Allenbach Y, Rosenzwajg M, Dolladille C, Salem JE.Nat Med. 2023 Oct 26. doi: 10.1038/s41591-023-02591-2. Online ahead of print.PMID: 37884625
Cardiomuscular Biomarkers in the Diagnosis and Prognostication of Immune Checkpoint Inhibitor Myocarditis. Lehmann LH, Heckmann MB, Bailly G, Finke D, Procureur A, Power JR, Stein F, Bretagne M, Ederhy S, Fenioux C, Hamwy O, Funck-Brentano E, Romano E, Pieroni L, Münster J, Allenbach Y, Anquetil C, Leonard-Louis S, Palaskas NL, Hayek SS, Katus HA, Giannitsis E, Frey N, Kaya Z, Moslehi J, Prifti E, Salem JE; International ICI-Myocarditis Registry Contributors.Circulation. 2023 Jun 15. doi: 10.1161/CIRCULATIONAHA.123.062405. Online ahead of print.PMID: 37317858
Patient-reported ability to walk 4 m and to wash: New clinical endpoints and predictors of survival in patients with pre-terminal cancer. Anker MS, Lena A, Roeland EJ, Porthun J, Schmitz S, Hadzibegovic S, Sikorski P, Wilkenshoff U, Fröhlich AK, Ramer LV, Rose M, Eucker J, Rassaf T, Totzeck M, Lehmann LH, von Haehling S, Coats AJS, Friede T, Butler J, Anker SD, Riess H, Landmesser U, Bullinger L, Keller U, Ahn J.J Cachexia Sarcopenia Muscle. 2023 Aug;14(4):1670-1681. doi: 10.1002/jcsm.13247. Epub 2023 May 24.PMID: 37222009
Effect of SARS-CoV-2 mRNA-Vaccine on the Induction of Myocarditis in Different Murine Animal Models. Zirkenbach VA, Ignatz RM, Öttl R, Cehreli Z, Stroikova V, Kaya M, Lehmann LH, Preusch MR, Frey N, Kaya Z.Int J Mol Sci. 2023 Mar 6;24(5):5011. doi: 10.3390/ijms24055011.
Abatacept/Ruxolitinib and Screening for Concomitant Respiratory Muscle Failure to Mitigate Fatality of Immune-Checkpoint Inhibitor Myocarditis. Salem JE, Bretagne M, Abbar B, Leonard-Louis S, Ederhy S, Redheuil A, Boussouar S, Nguyen LS, Procureur A, Stein F, Fenioux C, Devos P, Gougis P, Dres M, Demoule A, Psimaras D, Lenglet T, Maisonobe T, De Chambrun MP, Hekimian G, Straus C, Gonzalez-Bermejo J, Klatzmann D, Rigolet A, Guillaume-Jugnot P, Champtiaux N, Benveniste O, Weiss N, Saheb S, Rouvier P, Plu I, Gandjbakhch E, Kerneis M, Hammoudi N, Zahr N, Llontop C, Morelot-Panzini C, Lehmann L, Qin J, Moslehi JJ, Rosenzwajg M, Similowski T, Allenbach Y.Cancer Discov. 2023 May 4;13(5):1100-1115. doi: 10.1158/2159-8290.CD-22-1180.
2022
Hormonal therapies up-regulate MANF and overcome female susceptibility to immune checkpoint inhibitor myocarditis. Zhang Y, Sun C, Li Y, Qin J, Amancherla K, Jing Y, Hu Q, Liang K, Zhang Z, Ye Y, Huang LA, Nguyen TK, Egranov SD, Zhao Z, Wu A, Xi Y, Yao J, Hung MC, Calin GA, Cheng J, Lim B, Lehmann LH, Salem JE, Johnson DB, Curran MA, Yu D, Han L, Darabi R, Yang L, Moslehi JJ, Lin C.Sci Transl Med. 2022 Nov 2;14(669):eabo1981. doi: 10.1126/scitranslmed.abo1981. Epub 2022 Nov 2.PMID: 36322628
O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy. Schmiedel N, Remes A, Valadan M, Hille S, Matzen A, Frank D, Frey N, Lehmann L, Müller OJ.J Vis Exp. 2022 Oct 6;(188). doi: 10.3791/64455.PMID: 36282705
Coronary artery disease and revascularization associated with immune checkpoint blocker myocarditis: Report from an international registry. Nowatzke J, Guedeney P, Palaskas N, Lehmann L, Ederhy S, Zhu H, Cautela J, Francis S, Courand PY, Deswal A, Ewer SM, Aras M, Arangalage D, Ghafourian K, Fenioux C, Finke D, Peretto G, Zaha V, Itzhaki Ben Zadok O, Tajiri K, Akhter N, Levenson J, Baldassarre L, Power J, Huang S, Collet JP, Moslehi J, Salem JE; International ICI-myocarditis registry contributors.Eur J Cancer. 2022 Aug 24:S0959-8049(22)00443-9. doi: 10.1016/j.ejca.2022.07.018. Online ahead of print.PMID: 36030143
Association of early electrical changes with cardiovascular outcomes in immune checkpoint inhibitor myocarditis. Power JR, Alexandre J, Choudhary A, Ozbay B, Hayek SS, Asnani A, Tamura Y, Aras M, Cautela J, Thuny F, Gilstrap L, Arangalage D, Ewer S, Huang S, Deswal A, Palaskas NL, Finke D, Lehmann LH, Ederhy S, Moslehi J, Salem JE; International ICI-Myocarditis Registry.Arch Cardiovasc Dis. 2022 May;115(5):315-330. doi: 10.1016/j.acvd.2022.03.003. Epub 2022 Apr 27.
Cardio-oncology imaging tools at the translational interface.Yaros K, Eksi B, Chandra A, Agusala K, Lehmann LH, Zaha VG.J Mol Cell Cardiol. 2022 Apr 3;168:24-32. doi: 10.1016/j.yjmcc.2022.03.012
Coronary artery disease, left ventricular function and cardiac biomarkers determine all-cause mortality in cancer patients-a large monocenter cohort study.Finke D, Heckmann MB, Wilhelm S, Entenmann L, Hund H, Bougatf N, Katus HA, Frey N, Lehmann LH.Clin Res Cardiol. 2022 Mar 21. doi: 10.1007/s00392-022-02001-6. Online ahead of print.
2021
Cancer-A Major Cardiac Comorbidity With Implications on Cardiovascular Metabolism.Finke D, Heckmann MB, Frey N, Lehmann LH.Front Physiol. 2021 Nov 26;12:729713. doi: 10.3389/fphys.2021.729713. eCollection 2021.
Electrocardiographic Manifestations of Immune Checkpoint Inhibitor Myocarditis.Power JR, Alexandre J, Choudhary A, Ozbay B, Hayek S, Asnani A, Tamura Y, Aras M, Cautela J, Thuny F, Gilstrap L, Arangalage D, Ewer S, Huang S, Deswal A, Palaskas NL, Finke D, Lehmann L, Ederhy S, Moslehi J, Salem JE; International ICI-Myocarditis Registry†.Circulation. 2021 Nov 2;144(18):1521-1523. doi: 10.1161/CIRCULATIONAHA.121.055816. Epub 2021 Nov 1.
Histone deacetylase 4 deletion broadly affects cardiac epigenetic repression and regulates transcriptional susceptibility via H3K9 methylation.Finke D, Schanze LM, Schreiter F, Kreußer MM, Katus HA, Backs J, Lehmann LH.J Mol Cell Cardiol. 2021 Sep 4:S0022-2828(21)00173-5. doi: 10.1016/j.yjmcc.2021.09.001. Online ahead of print.PMID: 34492228
High-sensitivity cardiac troponin T determines all-cause mortality in cancer patients: a single-centre cohort study.Finke D, Romann SW, Heckmann MB, Hund H, Bougatf N, Kantharajah A, Katus HA, Müller OJ, Frey N, Giannitsis E, Lehmann LH.ESC Heart Fail. 2021 Aug 15. doi: 10.1002/ehf2.13515. Online ahead of print.PMID: 34396713
Clinical Strategy for the Diagnosis and Treatment of Immune Checkpoint Inhibitor-Associated Myocarditis: A Narrative Review.Lehmann LH, Cautela J, Palaskas N, Baik AH, Meijers WC, Allenbach Y, Alexandre J, Rassaf T, Müller OJ, Aras M, Asnani AH, Deswal A, Laufer-Perl M, Thuny F, Kerneis M, Hayek SS, Ederhy S, Salem JE, Moslehi JJ.JAMA Cardiol. 2021 Jul 7. doi: 10.1001/jamacardio.2021.2241. Online ahead of print
The Heidelberg cardio-oncology unit (COUNT)-a possible blueprint for improved care of cardio-oncological patients.Lehmann LH, Stein F, Jäger D, Frey N.Clin Res Cardiol. 2021 Jun 28. doi: 10.1007/s00392-021-01894-z. Online ahead of print.PMID: 34181066
Comparative Transcriptomics of Immune Checkpoint Inhibitor Myocarditis Identifies Guanylate Binding Protein 5 and 6 Dysregulation.Finke D, Heckmann MB, Salatzki J, Riffel J, Herpel E, Heinzerling LM, Meder B, Völkers M, Müller OJ, Frey N, Katus HA, Leuschner F, Kaya Z, Lehmann LH.Cancers (Basel). 2021 May 20;13(10):2498. doi: 10.3390/cancers13102498.
Early Detection of Checkpoint Inhibitor-Associated Myocarditis Using 68Ga-FAPI PET/CT.Finke D, Heckmann MB, Herpel E, Katus HA, Haberkorn U, Leuschner F, Lehmann LH.Front Cardiovasc Med. 2021 Feb 25;8:614997. doi: 10.3389/fcvm.2021.614997. eCollection 2021.PMID: 33718446
Epigenetic regulation of cardiac electrophysiology in atrial fibrillation: HDAC2 determines action potential duration and suppresses NRSF in cardiomyocytes.Lugenbiel P, Govorov K, Syren P, Rahm AK, Wieder T, Wunsch M, Weiberg N, Manolova E, Gramlich D, Rivinius R, Finke D, Lehmann LH, Schweizer PA, Frank D, El Tahry FA, Bruehl C, Heimberger T, Sandke S, Weis T, Most P, Schmack B, Ruhparwar A, Karck M, Frey N, Katus HA, Thomas D.Basic Res Cardiol. 2021 Feb 25;116(1):13. doi: 10.1007/s00395-021-00855-x.PMID: 33630168
2020
A genetic mouse model recapitulates immune checkpoint inhibitor-associated myocarditis and supports a mechanism-based therapeutic intervention. Wei SC, Meijers WC, Axelrod ML, Anang NAS, Screever EM, Wescott EC, Johnson DB, Whitley E, Lehmann L, Courand PY, Mancuso JJ, Himmel LE, Lebrun-Vignes B, Wleklinski MJ, Knollmann BC, Srinivasan J, Li Y, Atolagbe OT, Rao X, Zhao Y, Wang J, Ehrlich LIR, Sharma P, Salem JE, Balko JM, Moslehi JJ, Allison JP. Cancer Discov. 2020 Nov 30:CD-20-0856. doi: 10.1158/2159-8290.CD-20-0856. Online ahead of print. PMID: 33257470
Common mechanistic pathways in cancer and heart failure. A scientific roadmap on behalf of the Translational Research Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). de Boer RA, Hulot JS, Tocchetti CG, Aboumsallem JP, Ameri P, Anker SD, Bauersachs J, Bertero E, Coats AJS, Čelutkienė J, Chioncel O, Dodion P, Eschenhagen T, Farmakis D, Bayes-Genis A, Jäger D, Jankowska EA, Kitsis RN, Konety SH, Larkin J, Lehmann L, Lenihan DJ, Maack C, Moslehi JJ, Müller OJ, Nowak-Sliwinska P, Piepoli MF, Ponikowski P, Pudil R, Rainer PP, Ruschitzka F, Sawyer D, Seferovic PM, Suter T, Thum T, van der Meer P, Van Laake LW, von Haehling S, Heymans S, Lyon AR, Backs J. Eur J Heart Fail. 2020 Oct 22. doi: 10.1002/ejhf.2029. Online ahead of print.
[Mechanisms of cardiotoxicity of oncological therapies]. Lehmann LH, Fröhling S. Internist (Berl). 2020 Nov;61(11):1132-1139. doi: 10.1007/s00108-020-00881-2.
Relationship Between Cardiac Fibroblast Activation Protein Activity by Positron Emission Tomography and Cardiovascular Disease. Heckmann MB, Reinhardt F, Finke D, Katus HA, Haberkorn U, Leuschner F, Lehmann LH. Circ Cardiovasc Imaging. 2020 Sep;13(9):e010628. doi: 10.1161/CIRCIMAGING.120.010628. Epub 2020 Sep 11.
A Minimal-Invasive Approach for Standardized Induction of Myocardial Infarction in Mice. Sicklinger F, Zhang Y, Lavine K, Simon N, Bucher V, Jugold M, Lehmann L, Konstandin MH, Katus HA, Leuschner F. Circ Res. 2020 Aug 28. doi: 10.1161/CIRCRESAHA.120.317794.
Establishing an oncocardiology service. Lehmann LH, Totzeck M. Herz. 2020 Jun 22:1-6. doi: 10.1007/s00059-020-04952-w
Emerging role of immune checkpoint inhibitors and their relevance for the cardiovascular system. Michel L, Totzeck M, Lehmann L, Finke D. Herz. 2020 Jun 12. doi: 10.1007/s00059-020-04954-8
Onco-Cardiology: Consensus Paper of the German Cardiac Society, the German Society for Pediatric Cardiology and Congenital Heart Defects and the German Society for Hematology and Medical Oncology. Rassaf T, Totzeck M, Backs J, Bokemeyer C, Hallek M, Hilfiker-Kleiner D, Hochhaus A, Lüftner D, Müller OJ, Neudorf U, Pfister R, von Haehling S, Lehmann LH*, Bauersachs J*; Committee for Clinical Cardiovascular Medicine of the German Cardiac Society. Clin Res Cardiol. 2020 May 13. doi: 10.1007/s00392-020-01636-7. *equally contributed
Heart-Specific Immune Responses in an Animal Model of Autoimmune-Related Myocarditis Mitigated by an Immunoproteasome Inhibitor and Genetic Ablation. Bockstahler M, Fischer A, Goetzke CC, Neumaier HL, Sauter M, Kespohl M, Müller AM, Meckes C, Salbach C, Schenk M, Heuser A, Landmesser U, Weiner J, Meder B, Lehmann L, Kratzer A, Klingel K, Katus HA, Kaya Z, Beling A. Circulation. 2020 Jun 9;141(23):1885-1902. doi: 10.1161/CIRCULATIONAHA.119.043171.
2019
The lipid droplet-associated protein ABHD5 protects the heart through proteolysis of HDAC4. Jebessa ZH, Shanmukha Kumar D, Dewenter M, Lehmann LH, Xu C, Schreiter F, Siede D, Gong XM, Worst BC, Federico G, Sauer SW, Fischer T, Wechselberger L, Müller OJ, Sossalla S, Dieterich C, Most P, Gröne HJ, Moro C, Oberer M, Haemmerle G, Katus HA, Tyedmers J, Backs J. Nat Metab. 2019 Nov;1(11):1157-1167. doi: 10.1038/s42255-019-0138-4.
CaM kinase II regulates cardiac hemoglobin expression through histone phosphorylation upon sympathetic activation. Saadatmand AR, Sramek V, Weber S, Finke D, Dewenter M, Sticht C, Gretz N, Wüstemann T, Hagenmueller M, Kuenzel SR, Meyer-Roxlau S, Kramer M, Sossalla S, Lehmann LH, Kämmerer S, Backs J, El-Armouche A. Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22282-22287. doi: 10.1073/pnas.1816521116.
[Cardiac arrhythmias in oncological diseases, during radiotherapy, chemotherapy]. Lehmann LH, Katus HA, Scholz EP. Herzschrittmacherther Elektrophysiol. 2019 Sep;30(3):268-273. doi: 10.1007/s00399-019-00634-1.
Evidence for a cardiac metabolic switch in patients with Hodgkin’s lymphoma. Heckmann MB, Totakhel B, Finke D, Anker MS, Müller-Tidow C, Haberkorn U, Katus HA, Lehmann LH. ESC Heart Fail. 2019 Aug;6(4):824-829. doi: 10.1002/ehf2.12475. Epub 2019 Jul 6.
O-GlcNAcylation of Histone Deacetylase 4 Protects the Diabetic Heart From Failure. Kronlage M, Dewenter M, Grosso J, Fleming T, Oehl U, Lehmann LH, Falcão-Pires I, Leite-Moreira AF, Volk N, Gröne HJ, Müller OJ, Sickmann A, Katus HA, Backs J. Circulation. 2019 Aug 13;140(7):580-594. doi: 10.1161/CIRCULATIONAHA.117.031942.
CaMKII activation participates in doxorubicin cardiotoxicity and is attenuated by moderate GRP78 overexpression. Tscheschner H, Meinhardt E, Schlegel P, Jungmann A, Lehmann LH, Müller OJ, Most P, Katus HA, Raake PW. PLoS One. 2019 Apr 29;14(4):e0215992. doi: 10.1371/journal.pone.0215992.
Myofilament Ca2+ sensitivity correlates with left ventricular contractility during the progression of pressure overload-induced left ventricular myocardial hypertrophy in rats. Ruppert M, Bódi B, Korkmaz-Icöz S, Loganathan S, Jiang W, Lehmann L, Oláh A, Barta BA, Sayour AA, Merkely B, Karck M, Papp Z, Szabó G, Radovits T. J Mol Cell Cardiol. 2019 Apr;129:208-218. doi: 10.1016/j.yjmcc.2019.02.017.
Cardiovascular adverse events in multiple myeloma patients. Heckmann MB, Doroudgar S, Katus HA, Lehmann LH. J Thorac Dis. 2018 Dec;10(Suppl 35):S4296-S4305. doi: 10.21037/jtd.2018.09.87.
Experimental ischaemic stroke induces transient cardiac atrophy and dysfunction. Veltkamp R, Uhlmann S, Marinescu M, Sticht C, Finke D, Gretz N, Gröne HJ, Katus HA, Backs J, Lehmann LH. J Cachexia Sarcopenia Muscle. 2019 Feb;10(1):54-62. doi: 10.1002/jcsm.12335.
2018
Enzalutamide in Castration-Resistant Prostate Cancer. Anker MS, Lehmann LH, Anker SD. N Engl J Med. 2018 Oct 4;379(14):1380. doi: 10.1056/NEJMc1810065.
Pressure-volume analysis reveals characteristic sex-related differences in cardiac function in a rat model of aortic banding-induced myocardial hypertrophy. Ruppert M, Korkmaz-Icöz S, Loganathan S, Jiang W, Lehmann L, Oláh A, Sayour AA, Barta BA, Merkely B, Karck M, Radovits T, Szabó G. Am J Physiol Heart Circ Physiol. 2018 Sep 1;315(3):H502-H511. doi: 10.1152/ajpheart.00202.2018.
Cardio-oncology: conflicting priorities of anticancer treatment and cardiovascular outcome. Tilemann LM, Heckmann MB, Katus HA, Lehmann LH, Müller OJ. Clin Res Cardiol. 2018 Apr;107(4):271-280. doi: 10.1007/s00392-018-1202-x.
Inhibition of Endothelial Notch Signaling Impairs Fatty Acid Transport and Leads to Metabolic and Vascular Remodeling of the Adult Heart. Jabs M, Rose AJ, Lehmann LH, Taylor J, Moll I, Sijmonsma TP, Herberich SE, Sauer SW, Poschet G, Federico G, Mogler C, Weis EM, Augustin HG, Yan M, Gretz N, Schmid RM, Adams RH, Gröne HJ, Hell R, Okun JG, Backs J, Nawroth PP, Herzig S, Fischer A. Circulation. 2018 Jun 12;137(24):2592-2608. doi: 10.1161/CIRCULATIONAHA.117.029733.
A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway. Lehmann LH, Jebessa ZH, Kreusser MM, Horsch A, He T, Kronlage M, Dewenter M, Sramek V, Oehl U, Krebs-Haupenthal J, von der Lieth AH, Schmidt A, Sun Q, Ritterhoff J, Finke D, Völkers M, Jungmann A, Sauer SW, Thiel C, Nickel A, Kohlhaas M, Schäfer M, Sticht C, Maack C, Gretz N, Wagner M, El-Armouche A, Maier LS, Londoño JEC, Meder B, Freichel M, Gröne HJ, Most P, Müller OJ, Herzig S, Furlong EEM, Katus HA, Backs J. Nat Med. 2018 Jan;24(1):62-72. doi: 10.1038/nm.4452.
2017
Cerebral Microbleeds in Murine Amyloid Angiopathy: Natural Course and Anticoagulant Effects. Marinescu M, Sun L, Fatar M, Neubauer A, Schad L, van Ryn J, Lehmann L, Veltkamp R. Stroke. 2017 Aug;48(8):2248-2254. doi: 10.1161/STROKEAHA.117.017994.
Depletion of cardiac catecholamine stores impairs cardiac norepinephrine re-uptake by downregulation of the norepinephrine transporter. Kreusser MM, Lehmann LH, Haass M, Buss SJ, Katus HA, Lossnitzer D. PLoS One. 2017 Mar 10;12(3):e0172070. doi: 10.1371/journal.pone.0172070.
Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure. Abu-Taha IH, Heijman J, Hippe HJ, Wolf NM, El-Armouche A, Nikolaev VO, Schäfer M, Würtz CM, Neef S, Voigt N, Baczkó I, Varró A, Müller M, Meder B, Katus HA, Spiger K, Vettel C, Lehmann LH, Backs J, Skolnik EY, Lutz S, Dobrev D, Wieland T. Circulation. 2017 Feb 28;135(9):881-897. doi: 10.1161/CIRCULATIONAHA.116.022852.
2016
Inducible cardiomyocyte-specific deletion of CaM kinase II protects from pressure overload-induced heart failure. Kreusser MM, Lehmann LH, Wolf N, Keranov S, Jungmann A, Gröne HJ, Müller OJ, Katus HA, Backs J. Basic Res Cardiol. 2016 Nov;111(6):65. doi: 10.1007/s00395-016-0581-2.
Vorinostat in refractory soft tissue sarcomas – Results of a multi-centre phase II trial of the German Soft Tissue Sarcoma and Bone Tumour Working Group (AIO). Schmitt T, Mayer-Steinacker R, Mayer F, Grünwald V, Schütte J, Hartmann JT, Kasper B, Hüsing J, Hajda J, Ottawa G, Mechtersheimer G, Mikus G, Burhenne J, Lehmann L, Heilig CE, Ho AD, Egerer G. Eur J Cancer. 2016 Sep;64:74-82. doi: 10.1016/j.ejca.2016.05.018.
Oral treatment with a zinc complex of acetylsalicylic acid prevents diabetic cardiomyopathy in a rat model of type-2 diabetes: activation of the Akt pathway. Korkmaz-Icöz S, Al Said S, Radovits T, Li S, Brune M, Hegedűs P, Atmanli A, Ruppert M, Brlecic P, Lehmann LH, Lahrmann B, Grabe N, Yoshikawa Y, Yasui H, Most P, Karck M, Szabó G. Cardiovasc Diabetol. 2016 May 6;15:75. doi: 10.1186/s12933-016-0383-8.
2015
Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia. Schäfer M, Oeing CU, Rohm M, Baysal-Temel E, Lehmann LH, Bauer R, Volz HC, Boutros M, Sohn D, Sticht C, Gretz N, Eichelbaum K, Werner T, Hirt MN, Eschenhagen T, Müller-Decker K, Strobel O, Hackert T, Krijgsveld J, Katus HA, Berriel Diaz M, Backs J, Herzig S. Mol Metab. 2015 Nov 26;5(2):67-78. doi: 10.1016/j.molmet.2015.11.004.
Intercellular communication lessons in heart failure. Bang C, Antoniades C, Antonopoulos AS, Eriksson U, Franssen C, Hamdani N, Lehmann L, Moessinger C, Mongillo M, Muhl L, Speer T, Thum T. Eur J Heart Fail. 2015 Nov;17(11):1091-103. doi: 10.1002/ejhf.399.
Heat-shock-protein 90 protects from downregulation of HIF-1α in calcineurin-induced myocardial hypertrophy. Eschricht S, Jarr KU, Kuhn C, Lehmann L, Kreusser M, Katus HA, Frey N, Chorianopoulos E. J Mol Cell Cardiol. 2015 Aug;85:117-26. doi: 10.1016/j.yjmcc.2015.05.018.
Advanced echocardiography in adult zebrafish reveals delayed recovery of heart function after myocardial cryoinjury. Hein SJ*, Lehmann LH*, Kossack M, Juergensen L, Fuchs D, Katus HA, Hassel D. PLoS One. 2015 Apr 8;10(4):e0122665. doi: 10.1371/journal.pone.0122665. *equally contributed
2014
Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling. Lehmann LH, Rostosky JS, Buss SJ, Kreusser MM, Krebs J, Mier W, Enseleit F, Spiger K, Hardt SE, Wieland T, Haass M, Lüscher TF, Schneider MD, Parlato R, Gröne HJ, Haberkorn U, Yanagisawa M, Katus HA, Backs J. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13499-504. doi: 10.1073/pnas.1409026111.
CaM Kinase II mediates maladaptive post-infarct remodeling and pro-inflammatory chemoattractant signaling but not acute myocardial ischemia/reperfusion injury. Weinreuter M, Kreusser MM, Beckendorf J, Schreiter FC, Leuschner F, Lehmann LH, Hofmann KP, Rostosky JS, Diemert N, Xu C, Volz HC, Jungmann A, Nickel A, Sticht C, Gretz N, Maack C, Schneider MD, Gröne HJ, Müller OJ, Katus HA, Backs J. EMBO Mol Med. 2014 Oct;6(10):1231-45. doi: 10.15252/emmm.201403848.
Aldosterone augments Na+-induced reduction of cardiac norepinephrine reuptake. Kreusser MM, Lehmann LH, Riffel JH, Haass M, Maser-Gluth C, Backs J, Katus HA, Buss SJ. Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1169-77. doi: 10.1152/ajpheart.00193.2014.
Cardiac CaM Kinase II genes δ and γ contribute to adverse remodeling but redundantly inhibit calcineurin-induced myocardial hypertrophy. Kreusser MM, Lehmann LH, Keranov S, Hoting MO, Oehl U, Kohlhaas M, Reil JC, Neumann K, Schneider MD, Hill JA, Dobrev D, Maack C, Maier LS, Gröne HJ, Katus HA, Olson EN, Backs J. Circulation. 2014 Oct 7;130(15):1262-73. doi: 10.1161/CIRCULATIONAHA.114.006185.
Rapid and highly efficient inducible cardiac gene knockout in adult mice using AAV-mediated expression of Cre recombinase. Werfel S, Jungmann A, Lehmann L, Ksienzyk J, Bekeredjian R, Kaya Z, Leuchs B, Nordheim A, Backs J, Engelhardt S, Katus HA, Müller OJ. Cardiovasc Res. 2014 Oct 1;104(1):15-23. doi: 10.1093/cvr/cvu174.
Depletion of globosides and isoglobosides fully reverts the morphologic phenotype of Fabry disease. Porubsky S, Jennemann R, Lehmann L, Gröne HJ. Cell Tissue Res. 2014 Oct;358(1):217-27. doi: 10.1007/s00441-014-1922-9.
The role of endothelin-1 in the sympathetic nervous system in the heart. Lehmann LH, Stanmore DA, Backs J. Life Sci. 2014 Nov 24;118(2):165-72. doi: 10.1016/j.lfs.2014.03.005.
Histone deacetylase signaling in cardioprotection. Lehmann LH, Worst BC, Stanmore DA, Backs J. Cell Mol Life Sci. 2014 May;71(9):1673-90. doi: 10.1007/s00018-013-1516-9.
2013
HDAC4 controls histone methylation in response to elevated cardiac load. Hohl M, Wagner M, Reil JC, Müller SA, Tauchnitz M, Zimmer AM, Lehmann LH, Thiel G, Böhm M, Backs J, Maack C. J Clin Invest. 2013 Mar;123(3):1359-70. doi: 10.1172/JCI61084.
Inhibition of apoptosis by the intrinsic but not the extrinsic apoptotic pathway in myocardial ischemia-reperfusion. Kristen AV, Ackermann K, Buss S, Lehmann L, Schnabel PA, Haunstetter A, Katus HA, Hardt SE. Cardiovasc Pathol. 2013 Jul-Aug;22(4):280-6. doi: 10.1016/j.carpath.2013.01.004.
2012
Cardiac remodeling is not modulated by overexpression of muscle LIM protein (MLP). Kuhn C, Frank D, Dierck F, Oehl U, Krebs J, Will R, Lehmann LH, Backs J, Katus HA, Frey N. Basic Res Cardiol. 2012 May;107(3):262. doi: 10.1007/s00395-012-0262-8.
2011
Selective repression of MEF2 activity by PKA-dependent proteolysis of HDAC4. Backs J*, Worst BC*, Lehmann LH*, Patrick DM, Jebessa Z, Kreusser MM, Sun Q, Chen L, Heft C, Katus HA, Olson EN. J Cell Biol. 2011 Oct 31;195(3):403-15. doi: 10.1083/jcb.201105063. *equally contributed
2009
IMAGE CARDIO MED. A patient with LEOPARD syndrome and PTPN11 mutation. Lehmann LH, Schaeufele T, Buss SJ, Balanova M, Hartschuh W, Ehlermann P, Katus HA. Circulation. 2009 Mar 10;119(9):1328-9. doi: 10.1161/CIRCULATIONAHA.108.792861.
The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload. Backs J, Backs T, Neef S, Kreusser MM, Lehmann LH, Patrick DM, Grueter CE, Qi X, Richardson JA, Hill JA, Katus HA, Bassel-Duby R, Maier LS, Olson EN. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2342-7. doi: 10.1073/pnas.0813013106.
2008
Interstitial pneumonitis with accumulation of intraalveolar macrophages, a facet of amiodarone therapy. Lehmann LH, Weichert W, Schnapauff D, Dietz R, Stockburger M. Clin Res Cardiol. 2008 Dec;97(12):917-20. doi: 10.1007/s00392-008-0706-1.